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Lentinula Edodes/Shitake

Arinaga S., 1992.
Enhanced induction of lymphokine-activated killer after lentinan adminstration
in patients with gastric carcinoma.
Int. J. Immunopharmacol. 14(4), 535-53.

Brauer D, Kimmons T, Phillips M.
Effects of management on the yield and high-molecular-weight polysaccharide
content of shiitake (Lentinula edodes) mushrooms.
J Agric Food Chem. 2002 Sep 11;50(19):5333-7.

Breene W. M. 1989.
Nutritional & Medicinal Value of Exotic Mushrooms.
Shiitake Mushrooms.
The Proceeding of a National Symposium & Trade Show University of Minnesota 100-102

Brodziak L, 1984.
Nutritive value of the mushroom Lentinus edodes (Berk.) Sing.
(shiitake) compared with that of other edible mushrooms
Rocz Panstw Zakl Hig 35(1), 59-62

Chihara, G., Maeda, Y. Y. 1969 .
Inhibition of mouse sarcoma 180 by polysaccharides from lentinus edodes,
Nature, vol. 222, pg. 687.

Chihara G, 1970.
Antitumor polysaccharides, lentinan and pachymaran.
Saishin Igaku 25(5), 1043-1048

Chihara G, 1969.
Study on the antineoplastic activity and analysis of active fractions of Polyporaceae,
Lentinus edodes and other basidiomycetes.
Nippon Rinsho 27(6), 1739-174

Chihara G, 1987.
Antitumor and metastasis-inhibitory activities of lentinan as an immunomodulator: an overview.
Cancer Detect Prev Suppl 1, 423-443

Cozens, D.D. et al. 1981.
The effect of lentinan on fertility and general reproductive performance of the rat.
Toxicol. Lett. 9:55-64.

Dennart, G. and D. Tucker. 1973.
Antitumor polysaccharide Lentinan, a T cell adjuvant.
J. Natl. Cancer lnst. 51:1729.

Fang N, Li Q, Yu S, Zhang J, He L, Ronis MJ, Badger TM.
Inhibition of growth and induction of apoptosis in human cancer cell lines
by an ethyl acetate fraction from shiitake mushrooms.
J Altern Complement Med. 2006 Mar;12(2):125-32.

Feofilova EP, et al. 1998.
[Lipid composition of fruiting bodies and submerged mycelium from Lentinus edodes (Berk.) Sing].
Mikrobiologiia. 1998 Sep-Oct;67(5):655-9.

Flynn, V.T. 1991;
Is the shiitake mushroom an aphrodisiac and a cause of longevitvy?
From: Science and Cultivation of Edible Fungi (Maher, ed.). Rotterdam: Balkema.

Fruehauf JP, 1982.
The effect of lentinan on production of interleukin-1 by human monocytes.
Immunopharmacology 5(1), 65-7.

Fujita, A., et. al. 1969.
Determination of vitamin D by thin layer chromatography.
II. Determination of vitamin D in Shiitake Lentinus edodes. Vitamins 40: 129-135.

Gordon M, et al. 1998.
A placebo-controlled trial of the immune modulator, lentinan, in HIV-positive patients:
a phase I/II trial. Journal Medic. 29(5-6):305-30.

Kim HY, Kim JH, Yang SB, Hong SG, Lee SA, Hwang SJ, Shin KS, Suh HJ, Park MH.
A polysaccharide extracted from rice bran fermented with Lentinus edodes
enhances natural killer cell activity and exhibits anticancer effects.
J Med Food. 2007 Mar;10(1):25-31.

Kobayashi H, Kumagai F, Itagaki T, Koyama T, Inokuchi N, Iwama M, Ohgi K, Irie M.
Amino acid sequence and characterization of a nuclease (nuclease Le3) from Lentinus edodes.
Biosci Biotechnol Biochem. 2002 Jun;66(6):1345-55.

Maruyama S, Sukekawa Y, Kaneko Y, Fujimoto S.
[Anti tumor activities of lentinan and micellapist in tumor-bearing mice]
Gan To Kagaku Ryoho. 2006 Nov;33(12):1726-9.

Matsuoka H, 1997.
Lentinan potentiates immunity and prolongs the survival time of some patients.
Anticancer Res 17(4A), 2751-2755

atsuoka H, 1995.
Usefulness of lymphocyte subset change as an indicator for predicting
survival time and effectiveness of treatment with the immunopotentiator lentinan.
Anticancer Res 15(5B), 2291-2296

Miyaji CK, Poersch A, Ribeiro LR, Eira AF, Calus IM.
Shiitake (Lentinula edodes (Berkeley) Pegler) extracts as a modulator
of micronuclei induced in HEp-2 cells.
Toxicol In Vitro. 2006 Dec;20(8):1555-9.

Miyakoshi H, 1984.
Acting mechanisms of Lentinan in human--I. Augmentation of DNA synthesis
and immunoglobulin production of peripheral mononuclear cells.
Int J Immunopharmacol 6(4), 365-371

Mizoguchi, Y. et al. 1987.
Protection of liver cells against experimental damage by extract
of cultured Lentinus edodes mycelia (LEM).
Gast. Japonica 22:459-464.

Nakano H, et al. 1999.
A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life.
Kanagawa Lentinan Research Group. Hepatogastroenterology. Jul-Aug;46(28):2662-8.

Ng ML, Yap AT.
Inhibition of Human Colon Carcinoma Development by Lentinan from Shiitake Mushrooms (Lentinus edodes).
J Altern Complement Med. 2002 Oct;8(5):581-9

Odani S, et al. 1999.
The inhibitory properties and primary structure of a novel serine proteinase inhibitor from the fruiting body of the basidiomycete, Lentinus edodes.
Eur J Biochem. Jun;262(3):915-23.

Reverberi M, Fabbri AA, Zjalic S, Ricelli A, Punelli F, Fanelli C.
Antioxidant enzymes stimulation in Aspergillus parasiticus by Lentinula edodes
inhibits aflatoxin production.
Appl Microbiol Biotechnol. 2005

Sato T, et al. 1998.
Transformation of the edible basidiomycete Lentinus edodes
by restriction enzyme-mediated integration of plasmid DNA.
Biosci Biotechnol Biochem. 1998 Dec;62(12):2346-50.

Sia GM, et al. 1999.
Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line.
Phytother Res. 1999 Mar;13(2):133-7.

Soboleva AIu, Krasnopol'skaia LM, Fedorova GB, Katrukha GS.
[Antibiotic properties of the strains of the basidiomycete Lentinus edodes (Berk.) sing]
Antibiot Khimioter. 2006;51(7):3-8.

Sugano, N. et al. 1982.
Anticarcinogenic actions of water soluble ans alcohol insoluable fractions
of culture medium of Lentinus edodes mycelia.
Cancer Letters 17: 109-114.

Suzuki M, 1994.
Curative effects of combination therapy with lentinan
and interleukin-2 against established murine tumors, and the role of CD8-positive T cells.
Cancer Immunol Immunother 38(1), 1-8

Taguchi, T.1987.
Clinical efficacy of lentinan on patients with stomach cancer:
end point results of four-year follow-up survey. Cancer Detection & Prevention. Suppl. 1:333-49.

Takeshita K, 1991.
Diversity of complement activation by lentinan, an antitumor polysaccharide,
in gastric cancer patients
Nippon Geka Gakkai Zasshi 92(1), 5-11

Takatsuki F, 1995.
Lentinan augments skin reaction induced by bradykinin: its correlation
with vascular dilatation and hemorrhage responses and antitumor activities.
Int J Immunopharmacol 17(6), 465-474

Szeto CY, Wong QW, Leung GS, Kwan HS.
Isolation and transcript analysis of two-component histidine kinase gene Le.nik1
in Shiitake mushroom, Lentinula edodes.
Mycol Res. 2008 Jan;112(Pt 1):108-16. Epub 2007 Nov 21.

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Suga, T., Shiio, T., Maeda, YY., Chihara, G. 1994.
Anti tumor activity of lentinan in murine syngenetic
and autochthonous hosts and its suppressive effect
on 3 methylcholanthrene induced carcinogenesis.
Cancer Res. 44:5132-7.

Takehara, M. et al. 1983.
Antitumor effects of virus-like particles from Lentinus edodes (Shiitake)
on Ehrlich Acsites Carcinoma in mice.
Archiv Virology 68: 297-301.

Takeshita K, 1996.
Monocyte function associated with intermittent lentinan therapy after resection of gastric cancer.
Surg Oncol 5(1), 23-28

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